{"id":18108,"date":"2021-10-07T10:00:42","date_gmt":"2021-10-07T14:00:42","guid":{"rendered":"https:\/\/www.vrg.org\/blog\/?p=18108"},"modified":"2021-09-20T11:13:48","modified_gmt":"2021-09-20T15:13:48","slug":"whey-produced-from-a-genetic-code-is-it-animal-free","status":"publish","type":"post","link":"https:\/\/www.vrg.org\/blog\/2021\/10\/07\/whey-produced-from-a-genetic-code-is-it-animal-free\/","title":{"rendered":"Whey produced from a genetic code: Is It \u201cAnimal-Free\u201d?"},"content":{"rendered":"\n<figure class=\"wp-block-image\"><img loading=\"lazy\" decoding=\"async\" width=\"148\" height=\"148\" src=\"https:\/\/www.vrg.org\/blog\/wp-content\/uploads\/2021\/09\/126052705_1660428014135420_5763016471706237283_n.png\" alt=\"\" class=\"wp-image-18109\"\/><\/figure>\n\n\n\n<p>By Jeanne Yacoubou, MS<\/p>\n\n\n\n<p>The\nVRG has recently noticed several startup companies in the food ingredient space\nmarketing their products with an obvious appeal to vegans and vegetarians, as\nwell as to other consumers with certain dietary restrictions, such as the\nlactose intolerant. <\/p>\n\n\n\n<p>Here\nin Part 1 of a series, we look at the whey protein isolate manufactured by\nPerfect Day. <\/p>\n\n\n\n<p>On\ntheir website, Perfect Day is clear about how they manufacture their whey. They\nstart with a piece of a genetic code for <a href=\"https:\/\/resources.perfectdayfoods.com\/articles\/why-animal-free-dairy-still-contains-a-milk-allergen\" target=\"_blank\" rel=\"noreferrer noopener\">beta-lactoglobulin<\/a> (the scientific name for one form of whey). They\nfound this genetic information available for free on a website.<\/p>\n\n\n\n<p>The <em>actual<\/em>\ngenetic material on which the <em>virtual<\/em> genetic code is based was\ninitially taken from the blood of 8-year-old <a href=\"https:\/\/resources.perfectdayfoods.com\/articles\/how-we-teach-microflora-to-do-something-new\" target=\"_blank\" rel=\"noreferrer noopener\">L1 Dominette 01449<\/a>, a cow living in Montana, in 2009. Her blood was used\nin the Bovine Genome Project which mapped all 22,000 genes that make up the\nentire cow genetic signature.<\/p>\n\n\n\n<p>Perfect\nDay acquired the <a href=\"https:\/\/www.uniprot.org\/uniprot\/P02754\">bovine code<\/a>\nfrom a free online database called <em>UniProt<\/em> (abbreviation of <em>universal\nprotein resource<\/em>). <\/p>\n\n\n\n<p>Then\nPerfect Day inserted the genetic code for beta-lactoglobulin into <em>Trichoderma<\/em>,\na type of fungus. In a large fermentation tank growing on corn sugar, the\nmicrobes followed the genetic directions given to it. As a result, <em>Trichoderma<\/em>\nproduced large amounts of whey that were later separated and purified from the\nfermentation broth.<\/p>\n\n\n\n<p>The\nVRG wanted to know if cane sugar was ever used as the growth medium. This could\nbe an additional concern for some vegans and vegetarians if the cane sugar had\nbeen processed through a cow bone char filter.<\/p>\n\n\n\n<p>Through\nemail communication in July 2021, Kathleen Nay, Public Affairs and Content\nSpecialist at Perfect Day, informed The VRG:<\/p>\n\n\n\n<p>\u201cAt\npresent we use sugar derived from corn. However, our process is feedstock\nagnostic and can be adapted to local sugar production depending on where the\nfermentation takes place, to tap into or expand sugar markets. We certainly\ncould use cane sugar if the opportunity were there.\u201d <\/p>\n\n\n\n<p>So\nfar in 2021, this whey protein isolate is an ingredient in the \u201cvegan,\u201d\n\u201cplant-based,\u201d or \u201canimal-free\u201d ice cream products as marketed by these three\nbrands:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><a href=\"https:\/\/nicks.com\/collections#vegan-ice-cream\">Nick\u2019s<\/a> <\/li><li><a href=\"https:\/\/braverobot.co\/pages\/faqs\/\" target=\"_blank\" rel=\"noreferrer noopener\">Brave Robot<\/a> <\/li><li><a href=\"https:\/\/www.graeters.com\/shop-online\/new-perfect-indulgencetm\" target=\"_blank\" rel=\"noreferrer noopener\">Graeter\u2019s<\/a> <\/li><\/ul>\n\n\n\n<p>Graeter&#8217;s\nindicated on their website that their products contained animal-free whey and\ncasein (another milk protein). We checked into this with Perfect Day and\nlearned:<\/p>\n\n\n\n<p>\u201cAt\npresent we only supply animal-free whey protein to Graeter\u2019s, and their on-pack\ningredient labels reflect as much (the ingredient is listed as \u201cnon-animal whey\nprotein.\u201d)<\/p>\n\n\n\n<p>That said,\nanimal-free casein\/caseinates are actively in development. I suspect Graeter\u2019s\nteam developed their FAQs based on our own, which is why theirs mentions casein\nas well. It\u2019s certainly worth flagging to them \u2013 I will pass your note on to\nour relevant team members here who can touch base with Graeter\u2019s to clarify\ntheir website.\u201d<\/p>\n\n\n\n<p>According\nto Perfect Day&#8217;s website, their whey is functionally, genetically, and\nnutritionally equivalent to the whey in cow&#8217;s milk. Consequently, it provides\nthe same texture and taste in foods and beverages as cow&#8217;s milk whey. Perfect\nDay hopes to sell its product to other food companies that will use it in their\nwhey-containing items including soups, sauces, shakes, and snacks. <\/p>\n\n\n\n<p>Since\nwhey is a dairy allergen, <a href=\"https:\/\/www.fda.gov\/food\/food-allergensgluten-free-guidance-documents-regulatory-information\/food-allergen-labeling-and-consumer-protection-act-2004-questions-and-answers\" target=\"_blank\" rel=\"noreferrer noopener\">federal law<\/a> requires that it be flagged as such on food labels.\nThe words \u201cContains milk or milk ingredients\u201d are commonly seen on labels if\ndairy whey is present. <\/p>\n\n\n\n<p>In\nthe case of Perfect Day&#8217;s whey, its presence is indicated on labels by the\nwords \u201cContains milk protein\u201d or \u201cContains milk allergen.\u201d It has been <a href=\"https:\/\/www.foodnavigator-usa.com\/Article\/2020\/04\/14\/Perfect-Day-secures-no-objections-letter-from-FDA-for-non-animal-whey-protein\" target=\"_blank\" rel=\"noreferrer noopener\">approved<\/a> by the U.S. Food and Drug Administration (FDA). <\/p>\n\n\n\n<p><strong>Is whey from Perfect Day \u201canimal-free\u201d?<\/strong><\/p>\n\n\n\n<p>The\nVRG recognizes Perfect Day&#8217;s good intentions to move away from a reliance on\nconventional dairy cows as the source of its whey. We acknowledge the results\nof a recent <a href=\"https:\/\/www.foodnavigator-usa.com\/Article\/2021\/04\/19\/Leonardo-DiCaprio-hails-Perfect-Day-s-forward-looking-vision-as-lifecycle-assessment-shows-non-animal-whey-protein-has-far-lower-environmen\" target=\"_blank\" rel=\"noreferrer noopener\">lifecycle assessment<\/a> that quantified how many fewer greenhouse gas\nemissions are created from its whey production versus those released from\nraising live cows for milk. <\/p>\n\n\n\n<p>However,\non the question of whether their whey is \u201canimal-free,\u201d my personal view is\nthat it wouldn&#8217;t be. <\/p>\n\n\n\n<p>The\ngenetic blueprint for the whey is first and foremost <em>bovine<\/em>. This means\nthere is an animal product (an animal gene) directing the entire process. This\nis so even if a <em>copy<\/em> of the bovine gene was used rather than the actual\ngene isolated from Dominette&#8217;s blood. In other words, an animal product is\ninvolved in the whey&#8217;s manufacture as its initiator.<\/p>\n\n\n\n<p>It\nis true that the <em>copy<\/em> of the bovine gene that orchestrated the\nmanufacture does <em>not<\/em> become incorporated into the whey. Nor is it\nconsumed by the process since the gene is still an integral part of the genetic\nmakeup of <em>Trichoderma <\/em>fungiwhich are later separated from the\nwhey product. And obviously since genes are so tiny (but are so powerful in\ntheir action), only a small amount was needed. <\/p>\n\n\n\n<p>In\nall these ways, the copy of the bovine gene <em>loosely<\/em> sounds like a <em>processing\naid<\/em>. From an <a href=\"https:\/\/www.accessdata.fda.gov\/scripts\/cdrh\/cfdocs\/cfcfr\/cfrsearch.cfm?fr=101.100\">FDA document<\/a>\non exemptions to labeling, processing aids are thus partly defined:<\/p>\n\n\n\n<p>\u201c&#8230;Substances\nthat are added to a food during the processing of such food but are removed in\nsome manner from the food before it is packaged in its finished form.\u201d <\/p>\n\n\n\n<p>Viewing\nthe genetic code as a processing aid in this way, Perfect Day would be exempt\nfrom having to label their whey as <strong>animal gene-derived. <\/strong><\/p>\n\n\n\n<p>While\nit&#8217;s true that on its website the company describes its process as starting\nfrom animal genes, the phrase <em>animal gene-derived<\/em> is not specifically\nused there nor on the ice cream labels of brands (noted above) using its whey.\nThis term is needed so consumers will know beyond a doubt what they are\npurchasing.<\/p>\n\n\n\n<p>Many\nvegetarians and vegans do not buy or consume products manufactured with <em>any<\/em>\nanimal-derived processing aids or carriers even if the food or beverage is\notherwise vegan or vegetarian. Animal <a href=\"https:\/\/www.vrg.org\/journal\/vj2008issue3\/2008_issue3_update_renet.php\" target=\"_blank\" rel=\"noreferrer noopener\">rennet<\/a> in cheese making is the prime example. Another is\ngelatin in <a href=\"https:\/\/www.vrg.org\/blog\/2013\/02\/28\/\" target=\"_blank\" rel=\"noreferrer noopener\">fruit drinks<\/a>\nor <a href=\"https:\/\/www.vrg.org\/blog\/2012\/02\/15\/beta-carotene-in-us-beverages-not-stabilized-with-gelatin-unlike-some-products-in-the-uk\/\" target=\"_blank\" rel=\"noreferrer noopener\">butter\/margarine<\/a>.<\/p>\n\n\n\n<p>They\nmay not want to use Perfect Day&#8217;s whey based on similar reasoning. These\nindividuals may not see this whey as \u201cnon-animal\u201d or \u201canimal-free.\u201d<\/p>\n\n\n\n<p>If\nthis whey were added to \u201cplant-based\u201d products or items labeled as \u201cvegan\u201d or\n\u201cvegetarian,\u201d as it already is (see Nick&#8217;s ice cream brand above), it could\nlead to confusion and discontent. It would make some people feel misled, as if\nproducts intended for vegetarians and vegans were now covertly tainted with an\nanimal ingredient. In this case, it&#8217;s a microscopic gene inserted into fungi responsible\nfor the very existence of the ingredient. <\/p>\n\n\n\n<p>With more animal gene-derived ingredients under development, such as casein (milk protein) and <a href=\"https:\/\/resources.perfectdayfoods.com\/articles\/announcing-flora-made-fats\">milk fat<\/a> in the case of Perfect Day, and other animal gene-derived ingredients from other startups that The Vegetarian Resource Group will feature in upcoming blog posts, vegans and vegetarians are advised to seek more information from companies claiming their ingredients or products are \u201canimal-free\u201d or \u201cnon-animal.\u201d Find out if the genes are animal-derived or not.<\/p>\n\n\n\n<p>(Under\ncurrent circumstances) I predict that companies will eventually drop these\nterms entirely and just call their originally animal- or dairy-derived product\n\u201cvegan.\u201d If they do, they&#8217;ve supplanted the term <em>vegan<\/em> and redefined it.\n<\/p>\n\n\n\n<p>\u201c<strong>Animal\ngene-derived\u201d recommendation for labeling<\/strong><\/p>\n\n\n\n<p>The\nVRG recommends that all food and beverage companies be clear about the\nsource(s) of <em>all<\/em> their ingredients on their product labels, websites,\nand promotional materials. This recommendation applies also in cases where the\nonly animal ingredient was an animal&#8217;s gene used to direct its manufacture. <\/p>\n\n\n\n<p>It\nis only when companies are totally informative about how their ingredients were\nmade will vegetarians and vegans, as well as others with special dietary\npreferences, be able to purchase and consume foods and beverages with total\nconfidence about what they&#8217;re getting. <\/p>\n\n\n\n<p>Stay\ntuned to this blog for more posts on other startups producing\n&#8220;animal-free&#8221; or &#8220;non-animal&#8221; ingredients.<\/p>\n\n\n\n<p>NOTE\nFROM THE BLOG EDITOR: Vegetarians and vegans will have different viewpoints on these\nissues. The Food and Drug Administration and the United States Department of\nAgriculture have been asking for testimony for the development of labeling\nstandards re foods from cultured animal cells.&nbsp;With clear labeling,\nconsumers will be able to make their own decisions. <\/p>\n\n\n\n<p>For\ninformation on other ingredients, see <a href=\"https:\/\/www.vrg.org\/ingredients\/index.php\" target=\"_blank\" rel=\"noreferrer noopener\">https:\/\/www.vrg.org\/ingredients\/index.php<\/a><\/p>\n\n\n\n<p>To\nsupport The Vegetarian Resource Group research, donate at <a href=\"http:\/\/vrg.org\/donate\" target=\"_blank\" rel=\"noreferrer noopener\">vrg.org\/donate<\/a><\/p>\n\n\n\n<p>The\ncontents of this posting, our website, and our other publications, including\nVegetarian Journal, are not intended to provide personal medical advice.\nMedical advice should be obtained from a qualified health professional. We\noften depend on product and ingredient information from company statements. It\nis impossible to be 100% sure about a statement, info can change, people have\ndifferent views, and mistakes can be made. Please use your best judgment about whether\na product is suitable for you. To be sure, do further research or confirmation\non your own.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>By Jeanne Yacoubou, MS The VRG has recently noticed several startup companies in the food ingredient space marketing their products with an obvious appeal to vegans and vegetarians, as well as to other consumers with certain dietary restrictions, such as the lactose intolerant. Here in Part 1 of a series, we look at the whey [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-18108","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"_links":{"self":[{"href":"https:\/\/www.vrg.org\/blog\/wp-json\/wp\/v2\/posts\/18108","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.vrg.org\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.vrg.org\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.vrg.org\/blog\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.vrg.org\/blog\/wp-json\/wp\/v2\/comments?post=18108"}],"version-history":[{"count":2,"href":"https:\/\/www.vrg.org\/blog\/wp-json\/wp\/v2\/posts\/18108\/revisions"}],"predecessor-version":[{"id":18122,"href":"https:\/\/www.vrg.org\/blog\/wp-json\/wp\/v2\/posts\/18108\/revisions\/18122"}],"wp:attachment":[{"href":"https:\/\/www.vrg.org\/blog\/wp-json\/wp\/v2\/media?parent=18108"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.vrg.org\/blog\/wp-json\/wp\/v2\/categories?post=18108"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.vrg.org\/blog\/wp-json\/wp\/v2\/tags?post=18108"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}